Histone H2A.X (phospho Ser139) antibody
|Full Name||H2A histone family, member X|
|Synonyms||H2A.X antibody, histone H2A.x antibody, H2a/x antibody, MGC56329 antibody, zgc:56329 antibody, h2afx antibody, H2A histone family, member X antibody, Phospho zebrafish histone H2A X (S139) antibody, Phospho zebrafish histone H2A X (pS139) antibody, Phospho zebrafish histone H2A X (Ser139) antibody, zebrafish histone H2A X (S139) antibody, zebrafish histone H2A X (Ser139) antibody, zebrafish histone H2A X phospho phospho antibody, zebrafish histone H2A X phospho pS139 antibody, zebrafish histone H2A X (phospho phospho) antibody, zebrafish histone H2A X (phospho pS139) antibody|
|Product Description||Rabbit Polyclonal antibody to zebrafish histone H2A.X (phospho Ser139) (H2A histone family, member X)|
|Background||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
|Applications||IHC, IHC-P, IHC-Wm|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:2000*
|IHC (Whole mount)||1:100-1:500*
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||zebrafish embryo|
|Predicted Target Size||15 kDa|
|Purification||Purified by antigen-affinity chromatography.|
|Storage Buffer||1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Storage Instruction||Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.|
|Notes||For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |