Hsp90 alpha antibody
|Applications||ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||85 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , *RK3E |
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||heat shock protein 90kDa alpha (cytosolic), class A member 1|
|Product Description||Rabbit Polyclonal antibody to Hsp90 alpha (heat shock protein HSP 90-alpha)|
|Background||HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]|
|Synonyms||FLJ31884 antibody, HSP86 antibody, HSP89A antibody, HSP90A antibody, HSP90N antibody, HSPC1 antibody, HSPCA antibody, HSPCAL1 antibody, HSPCAL4 antibody, HSPN antibody, Hsp89 antibody, Hsp90 antibody, LAP2 antibody, HSP90AA1 antibody, HSP 86 antibody, "heat shock 90kD protein 1, alpha antibody", "heat shock 90kDa protein 1, alpha antibody", "heat shock 90kD protein, alpha-like 4 antibody", heat shock protein HSP 90-alpha antibody, "heat shock 90kD protein 1, alpha-like 4 antibody", renal carcinoma antigen NY-REN-38 antibody, heat shock 86 kDa antibody, "heat shock protein 90kDa alpha (cytosolic), class A member 1 antibody"|
|Cellular Localization||Cytoplasm , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Hsp90 alpha. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Pig (100%), Chicken (90%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (99%)|