|Full Name||isoleucyl-tRNA synthetase|
|Product Description||Rabbit Polyclonal antibody to IARS (isoleucyl-tRNA synthetase)|
|Background||Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. [provided by RefSeq]|
|Synonyms||PRO0785 Antibody , IRS Antibody , IARS1 Antibody , ILERS Antibody , isoleucyl-tRNA synthetase Antibody , ILRS Antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IARS. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (92%), Xenopus laevis (80%), Bovine (94%)|