|Full Name||DNA fragmentation factor, 45kDa, alpha polypeptide|
|Product Description||Rabbit Polyclonal antibody to ICAD (DNA fragmentation factor, 45kDa, alpha polypeptide)|
|Background||Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DFF-45 antibody, DFF1 antibody, ICAD antibody, DFFA antibody, DNA fragmentation factor 45 kDa subunit antibody, inhibitor of CAD antibody, DNA fragmentation factor subunit alpha antibody, DFF45 antibody, "DNA fragmentation factor, 45kDa, alpha polypeptide antibody"|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ICAD. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (83%), Rhesus Monkey (94%), Bovine (80%)|