IGF1R antibody [1H7] (Low endotoxin, azide free)
|Applications||FACS, IHC-P, WB, Functional Assay|
|IHC (Formalin-fixed paraffin-embedded sections)||1/10-1/40*
| Western blot||Assay-dependent dilution
| Functional Assay||Assay-dependent dilution
Flow cytometry/FACS : Use 10μl of the suggested working dilution to label 106 cells in 100μl.Not tested in other applications.
IHC (Formalin-fixed paraffin-embedded sections) : This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
*Optimal dilutions/concentrations should be determined by the researcher.
(Please refer to the vial label for the specific concentration)|
|Purification||Protein G purified|
|Purification Note||From tissue culture supernatant|
|Full Name||insulin like growth factor 1 receptor|
|Product Description||Mouse monoclonal antibody [1H7] to IGF1 Receptor|
|Background||This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]|
|Synonyms||IGFIR Antibody , IGFR Antibody , IGF1R Antibody , JTK13 Antibody , CD221 Antibody|
|Specificity||This antibody recognizes an epitope in the alpha subunits of IGF1R.Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to IGF1 Receptor (Li et al.1993).|
|Immunogen||Purified human placental IGF-I receptor.|