|Full Name||inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta|
|Product Description||Rabbit Polyclonal antibody to IKK beta (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)|
|Background||NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]|
|Synonyms||FLJ33771 antibody, FLJ36218 antibody, FLJ38368 antibody, FLJ40509 antibody, IKK-beta antibody, IKK2 antibody, IKKB antibody, MGC131801 antibody, NFKBIKB antibody, IKBKB antibody, IKK-B antibody, I-kappa-B kinase 2 antibody, I-kappa-B-kinase beta antibody, nuclear factor NF-kappa-B inhibitor kinase beta antibody, inhibitor of nuclear factor kappa-B kinase subunit beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human IKK beta. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (95%), Pig (92%), Chicken (82%), Rhesus Monkey (100%), Bovine (92%)|