|Full Name||IKAROS family zinc finger 1 (Ikaros)|
|Product Description||Rabbit Polyclonal antibody to IKZF1 (IKAROS family zinc finger 1 (Ikaros))|
|Background||Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). |
|Synonyms||Hs.54452 Antibody, PRO0758 Antibody, hIk-1 Antibody, IK1 Antibody, IKAROS family zinc finger 1 (Ikaros) Antibody, IKAROS Antibody, LYF1 Antibody, ZNFN1A1 Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human IKZF1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Chicken, Bovine|
|Predict Reactivity Note||Mouse (94%), Chicken (81%), Bovine (80%)|