|Full Name||interleukin 10|
|Product Description||Mouse Monoclonal antibody [GT5111] to IL10 (interleukin 10)|
|Background||The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq]|
|Synonyms||GVHDS Antibody , IL10A Antibody , TGIF Antibody , IL-10 Antibody , interleukin 10 Antibody , CSIF Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IL10. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Cat, Rabbit, Sheep, Rhesus Monkey, Chimpanzee, Bovine, Guinea pig|
|Predict Reactivity Note||Rat (80%), Dog (80%), Cat (86%), Rabbit (83%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (98%), Bovine (81%), Guinea pig (88%)|