IL12 Receptor beta2 antibody [N3C2], Internal
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||97 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji |
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||interleukin 12 receptor, beta 2|
|Product Description||Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2)|
|Background||The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]|
|Synonyms||IL12RB2 antibody, interleukin-12 receptor beta-2 chain antibody, IL-12 receptor subunit beta-2 antibody, interleukin-12 receptor subunit beta-2 antibody, IL-12R subunit beta-2 antibody, IL-12RB2 antibody, IL-12 receptor beta 2 antibody, IL-12R-beta-2 antibody, "interleukin 12 receptor, beta 2 antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Target||IL-12 Receptor beta2|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IL-12 Receptor beta2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Pig, Bovine|
|Predict Reactivity Note||Dog (80%), Pig (80%), Bovine (80%)|