| Full Name | interleukin 2 receptor, beta |
| Product Description | Rabbit Polyclonal antibody to IL2-R beta (phospho Tyr364) |
| Background | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008] |
| Synonyms | IL2RB Antibody , interleukin 2 receptor, beta Antibody , IL15RB Antibody , CD122 Antibody , P70-75 Antibody |
| Specificity | The antibody detects endogenous levels of IL-2Rβ/CD122 only when phosphorylated at tyrosine 364. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | IL2-R beta (phospho Tyr364) |
| Isotype | IgG |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 364(Q-G-Y(p)-F-F) derived from Human IL-2Rβ/CD122 . |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
| Conjugation | Unconjugated |