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Catalog Number
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GTX48248-PRO
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0
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Product Name
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IL33 Recombinant Protein (Active)
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| Full Name | interleukin 33 |
| Synonyms | IL33, NF-HEV, C9orf26, RP11575C20.2, DKFZp586H0523, RP11-575C20.2, DVS27, NFHEV, NF HEV |
| Background | Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues. |
| Species | Human |
| Region/Sequence | MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET |
| Expression System | E. coli |
| Applications | ELISA, WB, Functional Assay |
| Application Note | The ED50 was determined by the dose - dependent stimulation of the proliferation of murine D10S cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. |
| Conjugation | Unconjugated |
| Form Supplied | Lyophilized powder |
| Purity | Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
| Concentration | Batch dependent
(Please refer to the vial label for the specific concentration) |
| Storage Instruction | The lyophilized recombinant protein is stable for at least 2 years from date of receipt at -20˚C. After reconstitution, it is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. Avoid multiple freeze-thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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