|Full Name||interleukin 6 receptor|
|Product Description||Rabbit Polyclonal antibody to IL6 Receptor (interleukin 6 receptor)|
|Background||Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||CD126 antibody, IL-6R-1 antibody, IL-6R-alpha antibody, IL6RA antibody, MGC104991 antibody, IL6R antibody, CD126 antigen antibody, IL-6R 1 antibody, membrane glycoprotein 80 antibody, IL-6 receptor subunit alpha antibody, interleukin-6 receptor subunit alpha antibody, interleukin 6 receptor antibody|
|Cellular Localization||Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein , Isoform 2: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IL6 Receptor. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%), Pig (80%)|