|Full Name||leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2|
|Product Description||Rabbit polyclonal antibody to ILT-4 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2)|
|Background||This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CD85D antibody, ILT4 antibody, LILRA6 antibody, LIR-2 antibody, LIR2 antibody, MIR-10 antibody, MIR10 antibody, LILRB2 antibody, leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform antibody, "eukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 antibody", immunoglobulin-like transcript 4 antibody, leukocyte immunoglobulin-like receptor 2 antibody, CD85 antigen-like family member D antibody, ILT-4 antibody, leukocyte immunoglobulin-like receptor subfamily B member 2 antibody, monocyte/macrophage immunoglobulin-like receptor 10 antibody, Ig-like transcript 4 antibody, "leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ILT-4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (99%), Chimpanzee (84%)|