|Full Name||inositol(myo)-1(or 4)-monophosphatase 1|
|Product Description||Rabbit Polyclonal antibody to IMPA1 (inositol(myo)-1(or 4)-monophosphatase 1)|
|Background||This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq]|
|Synonyms||IMP antibody, IMPA antibody, IMPA1 antibody, IMPase 1 antibody, IMP 1 antibody, inositol-1(or 4)-monophosphatase 1 antibody, inositol monophosphatase 1 antibody, lithium-sensitive myo-inositol monophosphatase A1 antibody, inositol(myo)-1(or 4)-monophosphatase 1 antibody|
|Immunogen||Full length human IMPA1 Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (86%), Rat (84%), Pig (85%), Bovine (88%)|