|Full Name||inhibitor of growth family, member 3|
|Product Description||Rabbit polyclonal antibody to ING3 (inhibitor of growth family, member 3)|
|Background||The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq]|
|Synonyms||Eaf4 antibody, FLJ20089 antibody, ING2 antibody, MEAF4 antibody, p47ING3 antibody, ING3 antibody, inhibitor of growth protein 3 antibody, "inhibitor of growth family, member 3 antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ING3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Pig (100%), Bovine (100%)|