Full Name | interferon regulatory factor 3 |
Background | Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains. |
Cellular Localization | Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. |
Specificity | GTX84288 is specific for human IRF3. |
Host | Mouse |
Clonality | Monoclonal |
Clone Name | 4D4 |
Isotype | IgG2a |
Immunogen | Protein expressed in 293T cell transfected with human IRF3 expression vector |
Antigen Species | Human |
Species Reactivity | Human |
Conjugation | Unconjugated |