|Full Name||interferon regulatory factor 4|
|Product Description||Rabbit Polyclonal antibody to IRF4 (interferon regulatory factor 4)|
|Background||The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]|
|Synonyms||MUM1 Antibody, interferon regulatory factor 4 Antibody, LSIRF Antibody, NF-EM5 Antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IRF4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (91%), Rat (92%), Pig (93%), Chicken (87%), Rhesus Monkey (98%), Bovine (93%)|