|Full Name||integral membrane protein 2B|
|Product Description||Rabbit Polyclonal antibody to ITM2B (integral membrane protein 2B)|
|Background||Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq]|
|Synonyms||ABRI antibody, BRI antibody, BRI2 antibody, BRICD2B antibody, E25B antibody, E3-16 antibody, FBD antibody, ITM2B antibody, BRICHOS domain containing 2B antibody, integral membrane protein 2B antibody, transmembrane protein BRI antibody, ABri/ADan amyloid peptide antibody|
|Cellular Localization||Golgi apparatus membrane; Single-pass type II membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ITM2B. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (96%), Pig (95%), Sheep (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (96%)|