|Full Name||integral membrane protein 2C|
|Product Description||Rabbit Polyclonal antibody to ITM2C (integral membrane protein 2C)|
|Background||Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. |
|Synonyms||BRI3 antibody, BRICD2C antibody, E25 antibody, E25C antibody, ITM3 antibody, ITM2C antibody, BRICHOS domain containing 2C antibody, integral membrane protein 3 antibody, transmembrane protein BRI3 antibody, hRPC.1050_D_4 antibody, integral membrane protein 2C antibody, cerebral protein 14 antibody|
|Cellular Localization||Membrane; Single-pass type II membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (97%), Pig (98%), Chicken (81%), Sheep (97%), Bovine (97%)|