|Full Name||nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta|
|Product Description||Rabbit Polyclonal antibody to IkB beta (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta)|
|Background||NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]|
|Synonyms||IKBB antibody, TRIP9 antibody, NFKBIB antibody, TR-interacting protein 9 antibody, TRIP-9 antibody, ikappaBbeta antibody, I-kappa-B-beta antibody, ikB-B antibody, NF-kappa-BIB antibody, NF-kappa-B inhibitor beta antibody, ikB-beta antibody, thyroid receptor-interacting protein 9 antibody, "nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human IkB beta. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (84%), Rhesus Monkey (97%), Bovine (83%)|