|Full Name||insulin-degrading enzyme|
|Product Description||Goat polyclonal antibody to Insulysin / Insulinase|
|Background||Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. |
|Synonyms||Insulysin / Insulinase, insulysin, insulinase, insulin-degrading enzyme, FLJ35968, insulindegrading enzyme, insulin degrading enzyme|
|Cellular Localization||Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
|Specificity||This antibody is specific for Insulysin / Insulinase.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.