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Catalog Number
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GTX48181-PRO
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0
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Product Name
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Integrin alpha 4 Recombinant Protein
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| Full Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Synonyms | CD49d, ITGA4 |
| Product Description | Recombinant Human Integrin alpha 4 protein |
| Background | The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha 4 beta 1 and alpha 4 beta 7 is located on the alpha 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha 4 beta 7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha 4 beta 7, the gut mucosal homing receptor for peripheral T cells. This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 alpha (IN1) (PSI 4827) and Integrin 4 alpha (IN2) (PSI 4837), but not Integrin 4 alpha (CT) (PSI 4783). |
| Target | Integrin alpha 4 |
| Species | Human |
| Expression System | E. coli |
| Applications | ELISA, Neut, WB, MS |
| Form Supplied | Liquid |
| Purification Note | ~95% pure |
| Purity | ~95% pure |
| Storage Buffer | 50mM Tris pH7.5, 150mM NaCl, 5 mM MgCl2 |
| Storage Instruction | Store at -70ºC. As with any protein, exposing Integrin alpha 4 recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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