|Full Name||integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)|
|Product Description||Rabbit Polyclonal antibody to Integrin alpha V (integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51))|
|Background||ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||CD51 antibody, DKFZp686A08142 antibody, MSK8 antibody, VNRA antibody, ITGAV antibody, integrin alpha-V antibody, antigen identified by monoclonal antibody L230 antibody, vitronectin receptor subunit alpha antibody, "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Integrin alpha V. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Pig (92%), Sheep (90%), Rhesus Monkey (99%), Bovine (91%)|