|Full Name||Janus kinase 1|
|Product Description||Rabbit Polyclonal antibody to JAK1 (Janus kinase 1)|
|Background||Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq]|
|Synonyms||JAK1A antibody, JAK1B antibody, JTK3 antibody, JAK1 antibody, tyrosine-protein kinase JAK1 antibody, Janus kinase 1 antibody|
|Cellular Localization||Endomembrane system; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human JAK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Dog (96%), Pig (96%), Rhesus Monkey (99%), Bovine (96%)|