|Full Name||mitogen-activated protein kinase 8 interacting protein 1|
|Product Description||Rabbit Polyclonal antibody to JIP1 (mitogen-activated protein kinase 8 interacting protein 1)|
|Background||The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq]|
|Synonyms||IB1 antibody, JIP-1 antibody, JIP1 antibody, PRKM8IP antibody, MAPK8IP1 antibody, PRKM8 interacting protein antibody, JNK-interacting protein 1 antibody, IB-1 antibody, C-Jun-amino-terminal kinase-interacting protein 1 antibody, JNK MAP kinase scaffold protein 1 antibody, islet-brain 1 antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody|
|Cellular Localization||Cytoplasm (By similarity) , Cytoplasm , perinuclear region (By similarity) , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human JIP1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (94%), Bovine (94%)|