|Full Name||mitogen-activated protein kinase 8|
|Product Description||Rabbit Polyclonal antibody to JNK1 (mitogen-activated protein kinase 8)|
|Background||The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||JNK antibody, JNK1 antibody, JNK1A2 antibody, JNK21B1/2 antibody, PRKM8 antibody, SAPK1 antibody, MAPK8 antibody, mitogen-activated protein kinase 8 antibody, stress-activated protein kinase 1 antibody, stress-activated protein kinase 1c antibody, MAP kinase 8 antibody, c-Jun N-terminal kinase 1 antibody, JUN N-terminal kinase antibody, mitogen-activated protein kinase 8 isoform JNK1 alpha1 antibody, mitogen-activated protein kinase 8 isoform JNK1 beta2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human JNK1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (99%), Bovine (96%)|