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  • JNK (phospho Thr183/Tyr185) antibody

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1 .GTX50868 JNK (phospho Thr183/Tyr185) antibody

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JNK (phospho Thr183/Tyr185) antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsICC/IF, WB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX50868
Package Price Qty
100 μlUSD 319.00
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  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50868
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
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  • Datasheet
  • Application Information: JNK (phospho Thr183/Tyr185) antibody

Catalog Number GTX50868
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Product Name JNK (phospho Thr183/Tyr185) antibody
See all JNK products
ApplicationsICC/IF, WB
Application NoteSuggested starting dilutions are as follows. WB: 1:500~1:1000, ICC/IF: 1:100~1:200. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Predicted Target Size46, 54 (note)
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationAntibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

  • Specifications: JNK (phospho Thr183/Tyr185) antibody

BackgroundResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it./Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity
SynonymsJNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, MAPK8, mitogen-activated protein kinase 8, stress-activated protein kinase 1, stress-activated protein kinase 1c, MAP kinase 8, c-Jun N-terminal kinase 1, JUN N-terminal kinase, mitogen-activated protein kinase 8 isoform JNK1 alpha1, mitogen-activated protein kinase 8 isoform JNK1 beta2, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, p54a, p54aSAPK, MAPK9, stress-activated protein kinase 1a, MAP kinase 9, stress-activated protein kinase JNK2, Jun kinase, MAPK 9, c-Jun N-terminal kinase 2, c-Jun kinase 2, mitogen-activated protein kinase 9, FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK, MAPK10, MAPK 10, c-Jun N-terminal kinase 3, stress-activated protein kinase JNK3, stress activated protein kinase beta, JNK3 alpha protein kinase, MAP kinase 10, mitogen-activated protein kinase 10, MAP kinase p49 3F12, stress-activated protein kinase 1b
SpecificityThis antibody is raised against JNK1 phosphorylated at Thr183/Tyr185. Based on sequence homology, it is predicted to react with JNK3 when phosphorylated at the corresponding residues - Thr221/Tyr223.
HostRabbit
ClonalityPolyclonal
ImmunogenPeptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T(p)-P-Y(p)- V - V ) derived from Human JNK.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: JNK (phospho Thr183/Tyr185) antibody

Storage Buffersaline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Induction > Chemical stimulus
  • Cancer > Tumor biomarkers
  • Cancer > Type of cancer > Breast > Other
  • Cell Biology > Apoptosis > Induction from chemical stimulus
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JNK (phospho Thr183/Tyr185) antibody validated data
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
    • GTX50868 WB Image
      Western blot analysis of extracts from C6 cells untreated or treated with anisomycin using JNK1/JNK2/JNK3(phospho-Thr183/Tyr185) Antibody GTX50868.
      Top
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50868
    • GTX50868 ICC/IF Image
      Immunofluorescence staining of methanol-fixed Hela cells using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (GTX50868).
      Top
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
    • GTX50868 WB Image
      Western blot analysis of extracts from C6 cells untreated or treated with anisomycin using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (GTX50868).
      Top
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
    • GTX50868 WB Image
      Western blot analysis of extracts from C6 cells untreated or treated with anisomycin using JNK1/JNK2/JNK3(phospho-Thr183/Tyr185) Antibody GTX50868.
      Top
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50868
    • GTX50868 ICC/IF Image
      Immunofluorescence staining of methanol-fixed Hela cells using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (GTX50868).
      Top
  • Anti-JNK (phospho Thr183/Tyr185) antibody used in Western Blot (WB). GTX50868
    • GTX50868 WB Image
      Western blot analysis of extracts from C6 cells untreated or treated with anisomycin using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (GTX50868).
      Top
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