|Full Name||mitogen-activated protein kinase 10|
|Product Description||Rabbit Polyclonal antibody to JNK3 (mitogen-activated protein kinase 10)|
|Background||The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||FLJ12099 antibody, FLJ33785 antibody, JNK3 antibody, JNK3A antibody, MGC50974 antibody, PRKM10 antibody, p493F12 antibody, p54bSAPK antibody, MAPK10 antibody, MAPK 10 antibody, c-Jun N-terminal kinase 3 antibody, stress-activated protein kinase JNK3 antibody, stress activated protein kinase beta antibody, JNK3 alpha protein kinase antibody, MAP kinase 10 antibody, mitogen-activated protein kinase 10 antibody, MAP kinase p49 3F12 antibody, stress-activated protein kinase 1b antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human JNK3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Zebrafish (97%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%)|