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1 .GTX85363 JPH3 antibody

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JPH3 antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsELISA, IHC-P, WB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX85363
Package Price Qty
100 μgUSD 329.00
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  • Anti-JPH3 antibody used in Western Blot (WB). GTX85363
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
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  • Datasheet
  • Application Information: JPH3 antibody

Catalog Number GTX85363
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Product Name JPH3 antibody
See all JPH3 products
ApplicationsELISA, IHC-P, WB
Application Note
Suggested dilutionReference
ELISAAssay-dependent dilution  
IHC (Formalin-fixed paraffin-embedded sections)2.5 μg/mL*  
Western Blot (WB)1 μg/mL*  
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Positive ControlsHuman Brain Tissue Slide(GTX22203) , Daudi Cell Lysate(GTX23951)
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by antigen-affinity chromatography

  • Specifications: JPH3 antibody

Full Namejunctophilin 3
BackgroundJunctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.
SynonymsJunctophilin3, JPH3, JP3, Junctophilin 3, HDL2, JP-3, TNRC22, JP 3
SpecificityThis antibody is specific for JPH3 Internal
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenJPH3 antibody was raised against a 18 amino acid synthetic peptide near the center of human JPH3.The immunogen is located within amino acids 410 - 460 of JPH3.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: JPH3 antibody

Storage BufferPBS with 0.02% sodium azide.
Storage InstructionKeep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20° C or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Disorder > Huntington Disease
  • Neuroscience > Disorder > Huntington Disease
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JPH3 antibody validated data
  • Anti-JPH3 antibody used in Western Blot (WB). GTX85363
    • GTX85363 WB Image
      WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85363 JPH3 antibody.
      Working concentration : 1 μg/ml
      Top
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
    • GTX85363 IHC-P Image
      IHC-P analysis of human brain tissue using GTX85363 JPH3 antibody.
      Working concentration : 2.5 μg/ml
      Top
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
    • GTX85363 IHC-P Image
      IHC-P analysis of human brain tissue using GTX85363 JPH3 antibody.
      Working concentration : 20 μg/ml
      Top
  • Anti-JPH3 antibody used in Western Blot (WB). GTX85363
    • GTX85363 WB Image
      WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85363 JPH3 antibody.
      Working concentration : 1 μg/ml
      Top
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
    • GTX85363 IHC-P Image
      IHC-P analysis of human brain tissue using GTX85363 JPH3 antibody.
      Working concentration : 2.5 μg/ml
      Top
  • Anti-JPH3 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85363
    • GTX85363 IHC-P Image
      IHC-P analysis of human brain tissue using GTX85363 JPH3 antibody.
      Working concentration : 20 μg/ml
      Top
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