KCNJ1 / ROMK antibody, Internal
|Application Note||Approx. 45kDa band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 44.8kDa according to NP_000211.1). Recommended concentration: 1-3µg/ml. This antibody is expected to recognize reported isoforms NP_722449.2 and NP_000211. The following reported variants represent identical protein: NP_722451.1, NP_722449.2, NP_722450.1, NP_722448.1.|
|Predicted Target Size||44.8; 42.7 (note)
|Positive Controls||The peptide used to product this antibody is available for purchase (Catalog Number:GTX47558-PEP).|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.|
|Full Name||potassium inwardly-rectifying channel, subfamily J, member 1|
|Product Description||Goat polyclonal antibody to KCNJ1 / ROMK|
|Background||Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ATPsensitive inward rectifier potassium channel1, ATP-regulated potassium channel ROM-K, potassium inwardlyrectifying channel J1, inwardly recti, ATPsensitive inward rectifier potassium channel 1, ATPregulated potassium channel ROMK, ATP-sensitive inward rectifier potassium channel 1, potassium inwardly-rectifying channel J1, KCNJ1 / ROMK|
|Specificity||This antibody is specific for KCNJ1 / ROMK.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.