|Full Name||KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1|
|Product Description||Rabbit polyclonal antibody to KDEL receptor (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1)|
|Background||Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq]|
|Synonyms||ERD2 antibody, ERD2.1 antibody, HDEL antibody, PM23 antibody, KDELR1 antibody, ER lumen protein retaining receptor 1 antibody, KDEL endoplasmic reticulum protein retention receptor 1 antibody, putative MAPK-activating protein PM23 antibody, KDEL receptor 1 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein |
|Target||KDEL receptor |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human KDEL receptor. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (100%), Xenopus laevis (100%), Rhesus Monkey (100%), Bovine (100%)|