|Full Name||KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2|
|Product Description||Rabbit polyclonal antibody to KDELR2 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2)|
|Background||Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]|
|Synonyms||ELP-1 antibody, ERD2.2 antibody, FLJ45532 antibody, KDELR2 antibody, KDEL endoplasmic reticulum protein retention receptor 2 antibody, KDEL receptor 2 antibody, ERD-2-like protein antibody, (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 antibody, ERD2-like protein 1 antibody, ER lumen protein retaining receptor 2 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human KDELR2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%)|