|Full Name||killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4|
|Product Description||Rabbit Polyclonal antibody to KIR2DL4 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4)|
|Background||Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||CD158D antibody, G9P antibody, KIR103 antibody, KIR103AS antibody, KIR2DL4 antibody, natural killer cell inhibitory receptor antibody, CD158 antigen-like family member D antibody, killer Ig receptor antibody, NK cell receptor antibody, killer cell immunoglobulin-like receptor 2DL4 antibody, killer cell inhibitory receptor 103AS antibody, MHC class I NK cell receptor KIR103AS antibody, KIR-103AS antibody, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human KIR2DL4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Rhesus Monkey (89%), Chimpanzee (96%)|