|Full Name||kinesin light chain 1|
|Product Description||Rabbit polyclonal antibody to KLC1 (kinesin light chain 1)|
|Background||Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq]|
|Synonyms||KLC antibody, KNS2 antibody, KNS2A antibody, MGC15245 antibody, KLC1 antibody, kinesin 2 60/70kDa antibody, medulloblastoma antigen MU-MB-2.50 antibody, KLC 1 antibody, kinesin light chain 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human KLC1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (98%), Bovine (99%)|