|Full Name||karyopherin alpha 6 (importin alpha 7)|
|Product Description||Goat polyclonal antibody to KPNA6|
|Background||Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
|Synonyms||importin-alpha-S2, MGC17918, importin alpha 7 subunit, karyopherin alpha 6, KPNA7, KPNA6, IPOA7, karyopherin alpha 6 (importin alpha 7), importin alpha7 subunit, karyopherin alpha6 (importin alpha7), karyopherin alpha6, FLJ11249, importinalphaS2, importin alpha S2|
|Specificity||This antibody is specific for KPNA6.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|