|Full Name||KRIT1, ankyrin repeat containing|
|Product Description||Rabbit Polyclonal antibody to KRIT1 (KRIT1, ankyrin repeat containing)|
|Background||This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]|
|Synonyms||CAM antibody, CCM1 antibody, KRIT1 antibody, cerebral cavernous malformations 1 protein antibody, krev interaction trapped protein 1 antibody, ankyrin repeat-containing protein Krit1 antibody, krev interaction trapped 1 antibody, "KRIT1, ankyrin repeat containing antibody"|
|Cellular Localization||Membrane; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human KRIT1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (95%), Zebrafish (82%), Chicken (93%), Rhesus Monkey (99%), Bovine (98%)|