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  • Klotho antibody, Internal

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1 .GTX89443 Klotho antibody, Internal

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Klotho antibody, Internal


  • Host / ClonalityGoat Polyclonal
  • ApplicationsIHC-P
  • Species reactivityHuman
Cat No: GTX89443
Package Price Qty
100 μgUSD 319.00
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  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
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  • Datasheet
  • Application Information: Klotho antibody, Internal

Catalog Number GTX89443
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Product Name Klotho antibody, Internal
See all Klotho products
ApplicationsIHC-P
Application NotePreliminary experiments in human brain, duodenum, placenta and prostate lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? This antibody is expected to recognise both reported isoforms (NP_004786.2; NP_710150.1).
Positive ControlsThe peptide used to product this antibody is available for purchase (Catalog Number:GTX89443-PEP).
Form SuppliedLiquid
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

  • Specifications: Klotho antibody, Internal

Full Nameklotho
BackgroundMay have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
SynonymsKlotho, KL
Cellular LocalizationIsoform 1 shedding leads to a soluble peptide.
SpecificityThis antibody is specific for Klotho.
HostGoat
ClonalityPolyclonal
IsotypeIgG
ImmunogenC-KRDDAKYMYYLKK
Antigen SpeciesHuman
Species ReactivityHuman
Predicted Cross Reactivity species Predicted cross-reactivity:
    Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
    Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: Klotho antibody, Internal

Storage BufferTris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction Aliquot and store at -20°C. Minimize freezing and thawing.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Atherosclerosis
  • Disease Related > Cardiovascular > Blood > Erythrocyte
  • Disease Related > Cardiovascular > Heart > Heart disease
  • Disease Related > Cardiovascular > Vessels
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Klotho antibody, Internal validated data
  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
    • GTX89443 IHC-P Image
      GTX89443 (4µg/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
      Top
  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
    • GTX89443 IHC-P Image
      GTX89443 (4µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
      Top
  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
    • GTX89443 IHC-P Image
      GTX89443 (4µg/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
      Top
  • Anti-Klotho antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX89443
    • GTX89443 IHC-P Image
      GTX89443 (4µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
      Top
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All products are for research use only—Not for use in diagnostic procedures.