|Product Description||Rabbit Polyclonal antibody to Klotho (klotho)|
|Background||This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq]|
|Synonyms||KL antibody, klotho antibody|
|Cellular Localization||Isoform 1: Cell membrane; Single-pass type I membrane protein , Isoform 2: Secreted , Klotho peptide: Secreted |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Klotho. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Bovine (100%)|