APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
Assay dependent |
Assay dependent |
Assay dependent |
Assay dependent |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 1% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.8 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Peptide KDYPASTSQDSFEA(C), corresponding to amino acid residues 263-276 (Extracellular loop between domains S1 and S2) of human KV1.3 (Accession P22001).
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
potassium voltage-gated channel subfamily A member 3 , HGK5 , HLK3 , HPCN3 , HUKIII , KV1.3 , MK3 , PCN3
Cellular Localization
Cell membrane
Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX16679 WB Image
WB analysis of Jurkat cell lysates using GTX16679 Kv1.3 antibody preincubated with or without immunogen peptide. Dilution : 1:200
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GTX16679 LCI Image
Live cell imaging analysis of live intact HEK 293 cells transfected with rat KV1.3 (panels A and C) or with empty vector (panels B and D) using GTX16679 Kv1.3 antibody. Green : Primary antibody Dilution : 1:50
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GTX16679 WB Image
WB analysis of rat brain membrane lysate using GTX16679 Kv1.3 antibody preincubated with or without immunogen peptide. Dilution : 1:500
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GTX16679 FACS Image
FACS analysis of Jurkat cells using GTX16679 Kv1.3 antibody. Black : Unstained cell Green : Cell staining with primary antibody Dilution : 1:25
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REFERENCE
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REVIEW
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