|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||70 kDa (note)
|Positive Controls||A549 , H1299 , HCT116 , Raji , K562 , THP-1 , HL-60 , NIH-3T3 , JC , BCL-1|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||lymphocyte cytosolic protein 1 (L-plastin)|
|Product Description||Rabbit Polyclonal antibody to L-Plastin (lymphocyte cytosolic protein 1 (L-plastin))|
|Background||Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq]|
|Synonyms||CP64 antibody, DKFZp781A23186 antibody, FLJ25423 antibody, FLJ26114 antibody, FLJ39956 antibody, L-PLASTIN antibody, LC64P antibody, LPL antibody, PLS2 antibody, LCP1 antibody, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P) antibody, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)) antibody, plastin-2 antibody, plastin 2 antibody, LCP-1 antibody, Lymphocyte cytosolic protein-1 (plasmin) antibody, lymphocyte cytosolic protein 1 (L-plastin) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human L-Plastin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (97%), Zebrafish (86%), Xenopus laevis (88%), Chicken (92%), Rhesus Monkey (99%), Bovine (97%)|