|Full Name||L1 cell adhesion molecule|
|Product Description||Rabbit Polyclonal antibody to L1CAM (150kDa subunit) (L1 cell adhesion molecule)|
|Background||The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq]|
|Synonyms||NCAM-L1 Antibody , SPG1 Antibody , HSAS Antibody , N-CAM-L1 Antibody , CAML1 Antibody , MASA Antibody , N-CAML1 Antibody , S10 Antibody , CD171 Antibody , L1 cell adhesion molecule Antibody , HSAS1 Antibody , MIC5 Antibody , L1CAM Antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein |
|Target||L1CAM (150kDa subunit)|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human L1CAM (150kDa subunit). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (81%), Rat (81%), Rabbit (85%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (86%)|