| Full Name | L1 cell adhesion molecule |
| Product Description | Mouse monoclonal [UJ127] to L1CAM |
| Background | The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. |
| Synonyms | CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, N CAML1, NCAM L1, N CAM L1, NCAML1 |
| Specificity | GTX23200 is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin. It does not bind to pediatric or adult brain. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | UJ127 |
| Target | L1CAM |
| Isotype | IgG1 |
| Immunogen | Homogenous suspension of 16 week human fetal brain. |
| Light Chain | kappa |
| Antigen Species | Human |
| Species Reactivity | Human, Rat |