|Full Name||solute carrier family 7 (cationic amino acid transporter, y+ system), member 5|
|Product Description||Goat polyclonal antibody to LAT1 / SLC7A5|
|Background||Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. |
|Synonyms||Ltype amino acid transporter1, LAT1 / SLC7A5, large neutral amino acids transporter1, L-type amino acid transporter 1, large neutral amino acids transporter small subunit, D16S469E, Ltype amino acid transporter 1, large neutral amino acids transporter 1, sodiumindependent neutral amino acid transporter LAT1, sodium-independent neutral amino acid transporter LAT1, CD98, CD98 light chain, 4F2LC, E16, LAT1, MPE16, hLAT1|
|Cellular Localization||Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. |
|Specificity||This antibody is specific for LAT1 / SLC7A5.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.