|Full Name||lymphoid enhancer-binding factor 1|
|Product Description||Goat polyclonal antibody to LEF1|
|Background||Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
|Synonyms||lymphoid enhancerbinding factor 1, lymphoid enhancer-binding factor 1, DKFZp586H0919, LEF1, lymphoid enhancer binding factor1, TCF1ALPHA, lymphoid enhancerbinding factor1, lymphoid enhancer binding factor-1, HGNC:6551, FLJ46390|
|Cellular Localization||Found in nuclear bodies upon PIASG binding. |
|Specificity||This antibody is specific for LEF1.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.