|Full Name||lin-7 homolog B (C. elegans)|
|Product Description||Goat polyclonal antibody to LIN7B / MALS-2|
|Background||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface. |
|Synonyms||lin7 homolog B, LIN7B, Lin-7b protein likely ortholog of mouse LIN-7B mammalian LIN-7 protein 2, V, lin7 homolog B (C. elegans), Lin7b protein likely ortholog of mouse LIN7B mammalian LIN7 protein2, Lin7b protein likely ortholog of mouse LIN7B mammalian LIN7 protein 2, LIN-7B, LIN7B / MALS2, MALS-2, lin-7 homolog B, MALS2, VELI2, LIN 7B, MALS 2, lin 7 homolog B|
|Cellular Localization||Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. |
|Specificity||This antibody is specific for LIN7B / MALS-2.|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Dog, Pig, Bovine|