| Full Name | lipopolysaccharide-induced TNF factor |
| Background | Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Synonyms | FLJ38636 antibody, MGC116698 antibody, MGC116700 antibody, MGC116701 antibody, MGC125274 antibody, MGC125275 antibody, MGC125276 antibody, PIG7 antibody, SIMPLE antibody, TP53I7 antibody, LITAF antibody, LPS-induced TNF-alpha factor antibody, p53-induced gene 7 protein antibody, tumor protein p53 inducible protein 7 antibody, lipopolysaccharide-induced TNF-alpha factor antibody, lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody, small integral membrane protein of lysosome/late endosome antibody, lipopolysaccharide-induced TNF factor antibody |
| Cellular Localization | Lysosome membrane; Peripheral membrane protein; Cytoplasmic side |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human LITAF. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Mouse, Rat, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Mouse (85%), Rat (86%), Rhesus Monkey (96%), Bovine (86%) |
| Conjugation | Unconjugated |