|Full Name||lectin, mannose-binding, 1|
|Product Description||Rabbit Polyclonal antibody to LMAN1 (lectin, mannose-binding, 1)|
|Background||The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq]|
|Synonyms||ERGIC-53 antibody, ERGIC53 antibody, F5F8D antibody, FMFD1 antibody, MCFD1 antibody, MR60 antibody, gp58 antibody, LMAN1 antibody, endoplasmic reticulum-golgi intermediate compartment protein 53 antibody, protein ERGIC-53 antibody, ER-Golgi intermediate compartment 53 kDa protein antibody, intracellular mannose specific lectin antibody, intracellular mannose-specific lectin MR60 antibody, "lectin, mannose-binding, 1 antibody"|
|Cellular Localization||Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein , Golgi apparatus membrane; Single-pass membrane protein , Endoplasmic reticulum membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human LMAN1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Chicken (81%), Rhesus Monkey (97%), Bovine (95%)|