|Full Name||proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)|
|Product Description||Goat polyclonal antibody to PSMB8|
|Background||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. |
|Synonyms||proteasome beta 8 subunit, LMP7, low molecular weight protein 7, proteasomerelated gene7, proteasome catalytic subunit 3i, proteasome-related gene 7, proteasome catalytic subunit3i, OTTHUMP00000029421, low molecular weight protein7, macropain subunit C13, proteasome beta8 subunit, PSMB5i, proteasomerelated gene 7, multicatalytic endopeptidase complex subunit C13, D6S216, D6S216E, MGC1491, RING10, proteasome related gene 7|
|Specificity||This antibody is specific for PSMB8.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|