| Full Name | leucyl/cystinyl aminopeptidase |
| Background | This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Synonyms | P-LAP Antibody , PLAP Antibody , IRAP Antibody , leucyl/cystinyl aminopeptidase Antibody , CAP Antibody |
| Specificity | At least three isoforms are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, LNPEP often migrates at 165kD in SDS-PAGE. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | LNPEP antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human LNPEP.The immunogen is located within amino acids 900 - 950 of LNPEP. |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Unconjugated |