|Full Name||low density lipoprotein receptor-related protein 6|
|Product Description||Goat polyclonal antibody to LRP6|
|Background||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. |
|Synonyms||low density lipoprotein-related protein 6, FLJ90062, low density lipoproteinrelated protein6, ADCAD2, LRP6, low density lipoprotein receptorrelated protein 6, low density lipoprotein receptor-related protein 6, FLJ90421, low density lipoprotein receptorrelated protein6, low density lipoproteinrelated protein 6|
|Cellular Localization||On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmit|
|Specificity||This antibody is specific for LRP6.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog|